Assassin's Creedin isänä muistettava Patrice Désilets lähti Ubisoftilta tehdäkseen jotain uutta. Hän palasi kuitenkin takaisin muutaman vuoden kuluttua työstämään peliä 1666: Amsterdam. Sittemmin Désilets lähti Ubisoftilta uudelleen, ja hänellä kesti pitkään saada 1666: Amsterdamin oikeudet itselleen.
Nyt kun miehen Ancestors: The Humankind Odyssey on saatu konsoleille, hän siirtynee tekemään kauan työn alla ollutta 1666: Amsterdamia. Asian paljasti WCCFTech.
"I dunno...I've been talking about [1666 Amsterdam] since I got the rights back to it. Yeah, I want to make that game. The chances that it's my next one are really, really high. In my head, I started it. I went back to what I designed in 2011 and 2012 and said, what do I want to do? Now it's the game after Ancestors and not Assassin's Creed II. I'm a different person and designer and have a new team, so it's going to change. Ancestors is going to be how Panache does games in the future. That's our signature. So...1666 will not be an easy game. Eventually I'll announce it for real. The elevator pitch is really simple -- do you want to play the devil in 1666 Amsterdam by the guy who did Assassin's Creed and Ancestors?"